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Image Search Results
Journal: medRxiv
Article Title: EHMT2 LOSS-OF-FUNCTION ALTERATIONS CAUSE A KLEEFSTRA-LIKE SYNDROME
doi: 10.1101/2024.01.10.24300997
Figure Lengend Snippet: Molecular alterations in EHMT2 catalytic domain caused by the p.Ala1077Ser change. A. Measure of cumulative methyltransferase activity over time (seconds) using 250 ng of the catalytic domain of EHMT2 wild type (WT) or p.Ala1077Ser mutant and 2.5 µg of recombinant histone H3 as a substrate. Graph shows the mean and standard deviation of two replicates B. Specific activity in nmol/min/mg of WT and p.Ala1077Ser catalytic domains. Mean and standard deviation of two replicates is shown. C. Coomassie blue stained gel depicting the interaction of WT and Ala1077 catalytic domains with histone H3 peptides amino acids 1 to 21 unmodified (H3), monomethylated at lysine 9 (H3k9me1) and dimethylated at lysine 9 (H3k9me3) D. Quantification of WT and p.Ala1077Ser catalytic domains binding to peptides relative to input. Mean and standard deviation of three quantifications is shown. P-values for comparisons between WT and p.Ala1077Ser correspond to *<0.05, **<0.005 and ***<0.0005
Article Snippet: Histone methyltransferase assays were performed using the
Techniques: Activity Assay, Mutagenesis, Recombinant, Standard Deviation, Staining, Binding Assay
Journal: Frontiers in Microbiology
Article Title: mRNA vaccines: A novel weapon to control infectious diseases
doi: 10.3389/fmicb.2022.1008684
Figure Lengend Snippet: Clinical application of COVID-19 mRNA vaccine (from https://www.who.int/publications/m/item/draft-landscape-of-covid-19-candidate-vaccines , 30 August 2022).
Article Snippet: RNA based ,
Techniques: Expressing, Binding Assay, Plasmid Preparation, Vaccines
Journal: Frontiers in Microbiology
Article Title: mRNA vaccines: A novel weapon to control infectious diseases
doi: 10.3389/fmicb.2022.1008684
Figure Lengend Snippet: Preclinical study of A COVID-19 mRNA vaccine (from https://www.who.int/publications/m/item/draft-landscape-of-covid-19-candidate-vaccines , 30 August 2022).
Article Snippet: RNA based ,
Techniques: Derivative Assay, Plasmid Preparation, Variant Assay, Recombinant, Vaccines